Inhibition of human alkaline phosphatases by vanadate.
نویسندگان
چکیده
Orthovanadate was shown to be a potent competitive inhibitor (Ki less than 1 microM) of purified alkaline phosphatase from human liver, intestine of kidney. Inhibition was reversed and full enzymic activity restored in the presence of 1mM-adrenaline. Phosphate and vanadate competed for the same binding site on the enzyme.
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عنوان ژورنال:
- The Biochemical journal
دوره 181 1 شماره
صفحات -
تاریخ انتشار 1979